Hydrophilic or Lipophilic Statins? - PMC - National Center for ...
WEBMay 20, 2021 · The classification of drugs as hydrophilic or lipophilic depends on their ability to dissolve in lipid media or in water. The predominantly lipophilic statins can easily enter cells and interact with cell membranes, whereas hydrophilic statins present greater hepatoselectivity.
Insoluble drug delivery strategies: review of recent advances …
WEBSep 1, 2015 · Water insoluble drugs often have greater affinity for hydrophobic solvents because of hydrophobic–hydrophobic interactions and also have affinity for hydrophobic region of micelles. Hence encapsulation of those drugs in micelles enables their formulation in aqueous vehicle.
Bioavailability Enhancement Techniques for Poorly Aqueous Soluble Drugs …
WEBAug 23, 2022 · Hydrophobic drugs, along with cyclodextrin–drug complexes, are identified for aggregate formation in the aqueous medium. Surface-active preservatives and water-soluble polymers are well-known excipients for the solubility of the drug in an aqueous medium [116,117].
Hydrogels for Hydrophobic Drug Delivery. Classification, …
WEBJan 24, 2018 · This review describes hydrogel-based systems for hydrophobic compound delivery included in the literature. The section covers all the main types of hydrogels, including physical hydrogels and chemical hydrogels. Additionally, reported applications of these hydrogels are described in the subsequent sections.
Recent advancements in solubilization of hydrophobic drugs
WEBJan 1, 2020 · The slow and incomplete dissolution of such drugs in the gastrointestinal (GI) fluids limits their oral bioavailability and is a major problem in drug development (Vinarov et al., 2018). The recent discoveries highlight the potential of several new synthesized drugs.
Hydrophobicity: The door to drug delivery - Wiley Online Library
WEBDec 19, 2023 · 2 INTRODUCTION. Crossing biological barriers represents a crucial health challenge, as many therapeutic molecules, extremely beneficial in the fight against a specific pathology, often fail in entering cells, penetrating the central nervous system (CNS), or being administered orally to patients.
Hydrogels for Hydrophobic Drug Delivery. Classification
WEBJan 24, 2018 · This review describes hydrogel-based systems for hydrophobic compound delivery included in the literature. The section covers all the main types of hydrogels, including physical hydrogels and chemical hydrogels.
A smart viral vector for targeted delivery of hydrophobic drugs …
WEBMar 29, 2021 · Effective encapsulation of hydrophobic drugs in nano-vehicles can improve their pharmacokinetics, bioavailability and prevent off-target localization.
Hydrophilic or Lipophilic Statins? - PubMed
WEBMay 20, 2021 · Drugs can be classified as hydrophilic or lipophilic depending on their ability to dissolve in water or in lipid-containing media. The predominantly lipophilic statins (simvastatin, fluvastatin, pitavastatin, lovastatin and atorvastatin) can easily enter cells, whereas hydrophilic statins (rosuvasta ….
Solubility Enhancement of Hydrophobic Drugs - MilliporeSigma
WEBFigure 1. Schematic example of drug-loaded micelles. Coumarin-6 (C6) is traditionally used as a laser dye due to its highly fluorescent nature. Recently, however, it is commonly used as a model hydrophobic drug for studies involving controlled release and tracking of localized delivery.
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