Antigen Tests for Dengue Virus | Dengue | CDC - Centers for …
WEBMay 14, 2024 · NS1 antigen testing is recommended to determine dengue infections during the first 7 days of illness. A positive NS1 test result confirms dengue virus infection without providing serotype information.
Dengue virus non-structural protein 1: a pathogenic factor, …
WEBJul 24, 2018 · DENV nonstructural protein 1 (NS1), which can be secreted in patients’ sera, has been used as an early diagnostic marker for dengue infection for many years. However, the roles of NS1 in dengue-induced vascular …
Serologic Tests for Dengue Virus | Dengue | CDC - Centers for …
WEBKey points. Dengue IgM antibody testing is recommended in combination with nucleic acid amplification tests (NAAT) or NS1 antigen tests during the first 7 days of illness. IgM levels are positive starting 4–5 days after onset of symptoms and continuing for approximately 12 weeks post symptom onset but may persist longer.
Clinical Testing Guidance for Dengue | Dengue | CDC
WEBAug 26, 2024 · Patients with a positive NAAT (E.g., RT-PCR) or NS1 ELISA test have a confirmed acute dengue virus infection. Patients who have IgM antibodies against dengue virus in a single sample are classified as having a …
The Dengue Virus Nonstructural Protein 1 (NS1) Is Secreted from ...
WEBFeb 2, 2019 · The dengue virus protein NS1 is secreted efficiently from both infected vertebrate and mosquito cells. Previously, our group reported that NS1 secretion in mosquito cells follows an unconventional secretion pathway dependent on caveolin-1.
The Dengue Virus Nonstructural Protein 1 (NS1) Is Secreted from ...
WEBFeb 5, 2019 · Nonstructural protein 1 (NS1) is a multifunctional protein actively secreted in vertebrate and mosquito cells during infection. In mosquito cells, NS1 is secreted in a caveolin-1-dependent manner by an unconventional route.
Viral Toxin NS1 Implication in Dengue Pathogenesis Making It …
WEBAug 25, 2021 · Research has shown that the secreted soluble hexameric form of DENV nonstructural protein-1 (sNS1) plays a significant role in the pathogenesis of severe dengue. Here, we provide an overview of the current knowledge about the role of sNS1 in the immunopathogenesis of dengue disease.
Dengue Virus Non-structural Protein 1 Modulates Infectious
WEBNov 12, 2015 · Non-structural protein 1 (NS1) is one of the most enigmatic proteins of the Dengue virus (DENV), playing distinct functions in immune evasion, pathogenesis and viral replication.
Dengue Virus NS1 Uses Scavenger Receptor B1 as a Cell …
WEBMar 9, 2022 · Circulating NS1 has been associated with dengue pathogenesis by several mechanisms, including favoring of virus replication in hepatocytes and dendritic cells and disruption of the endothelial glycocalyx leading to hyperpermeability. Those last actions require NS1 internalization.
The N and C-terminal deleted variant of the dengue virus NS1
WEBAug 14, 2024 · NS1 is an elusive dengue protein, involved in viral replication, assembly, pathogenesis, and immune evasion. Its levels in blood plasm are positively related to disease severity like...
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