Antioch is the third-most populous city in Contra Costa County, California, United States. The city is located in the East Bay region of the San Fr…Antioch is the third-most populous city in Contra Costa County, California, United States. The city is located in the East Bay region of the San Francisco Bay Area along the Sacramento–San Joaquin River Delta. The city's population was 115,291 at the 2020 census. The city has grown substantially more diverse since the 1970s.
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