The Pittsburgh Pirates (29-42) visit the Chicago Cubs (42-28) Saturday for the third game of their 4-game series. First pitch from Wrigley Field is at 2:20 p.m. ET. Let's analyze BetMGM Sportsbook's MLB odds around the Pirates vs. Cubs odds and make our expert MLB picks and predictions for the best bets.

The Pittsburgh Pirates toppled the Chicago Cubs 2-1 on Friday afternoon at Wrigley Field as starting pitcher Paul Skenes continued his historic dominance away from PNC Park. Per Greg Harvey of OptaSTATS: Players in MLB history to have a sub-1.

Our MLB betting picks will toss Matthew Boyd's career splits vs. the Pirates out the window and bank on him shutting down a sorry version of Pittsburgh's offense on Saturday, June 14, 2025.