The actress, who stars alongside Demi Moore in the body horror film, says it took "probably a year" for her skin to recover.

The Substance costume designer Emmanuelle Youchnovski revealed in an interview with Next Best Picture that one of Margaret Qualley’s outfits as Sue in the Golden Globe-nominated body horror masterpiece was inspired by the “Houdini” singer, as well as Beyoncé.

Qualley stars in the film opposite Demi Moore, who plays an aging film star Elisabeth Sparkle. Sparkle takes the "substance" in order to transform into Sue (Qualley) but there's a catch: the pair must switch back every seven days. If they don't, Sue will begin deteriorating (and, it turns out, so will Sparkle).

While Margaret Qualley has garnered high praise for her performance in 2024’s The Substance, she has revealed that the extensive amount of prosthetics that were required for the film took a toll on her skin.

The actress recalled what it was like working with prosthetics for her role in the body horror film, which also stars Demi Moore.

During a recent appearance on the Happy Sad Confused podcast, Margaret Qualley revealed that the prosthetics she wore in "The Substance" "f--ked up" her skin, saying that it took "a year" for her skin to fully recover from the acne.

"It took me probably, like, a year to recover physically from all of it," she told a podcast about the prosthetics used in the film.

The actress spoke about dealing with acne caused by the movie makeup on Josh Horowitz's 'Happy Sad Confused' podcast

Margaret Qualley is proving she’s a Hollywood force in her own right. As if her striking features, raven hair and charming smile weren’t enough to showcase that she was destined for the screen, her acting chops and rapidly growing resume should be.

In The Substance, Margaret Qualley's character turns into an overnight superstar. So naturally, the film's costume director Emmanuelle Youchnovski turned to some real-life idols for inspiration - including Beyoncé and Dua Lipa.