The actress, who stars alongside Demi Moore in the body horror film, says it took "probably a year" for her skin to recover.

The Substance costume designer Emmanuelle Youchnovski revealed in an interview with Next Best Picture that one of Margaret Qualley’s outfits as Sue in the Golden Globe-nominated body horror masterpiece was inspired by the “Houdini” singer, as well as Beyoncé.

The actress recalled what it was like working with prosthetics for her role in the body horror film, which also stars Demi Moore.

Margaret Qualley and Demi Moore were both transformed for their roles in 'The Substance.' According to Qualley, it took her "probably a year to recover physically from all of it."

Adhesive materials, artificial skin, and layers of heavy makeup used to create these effects can often clog pores

Qualley went on the Happy Sad Confused podcast in January, and confessed that the prosthetics she wore in The Substance messed up her skin so bad that by the end of filming they had to find ways to avoid shooting her face.

"It took me probably, like, a year to recover physically from all of it," she told a podcast about the prosthetics used in the film.

During a recent appearance on the Happy Sad Confused podcast, Margaret Qualley revealed that the prosthetics she wore in "The Substance" "f--ked up" her skin, saying that it took "a year" for her skin to fully recover from the acne.

In The Substance, Hollywood star Elisabeth Sparkle (Demi Moore) is fired from her aerobics show when she turns 50. This leads her to seek out a drug called The Substance. After taking the drug, Elisabeth births a younger version of herself who she shares a consciousness with - the catch is she has to alternate living as each every seven days.

Margaret Qualley is proving she’s a Hollywood force in her own right. As if her striking features, raven hair and charming smile weren’t enough to showcase that she was destined for the screen, her acting chops and rapidly growing resume should be.

In The Substance, Margaret Qualley's character turns into an overnight superstar. So naturally, the film's costume director Emmanuelle Youchnovski turned to some real-life idols for inspiration - including Beyoncé and Dua Lipa.