The AMP-activated protein kinase (AMPK) is a central regulator of cellular energy homeostasis, acting as a metabolic sensor that responds to changes in intracellular AMP/ATP ratios. When cellular ...

An illustration shows the structure of an inhibitor bound to the active site of membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase. An inhibitor bound to the active site of ...

AMP-activated protein kinase (AMPK) plays a central role in maintaining energy balance in cells, especially under energy stress. While upstream activation by the kinase LKB1 is well recognized, the ...

Comprehending the significance of protein kinases in diseases such as cancer is pivotal for advancing drug development. Scientists at Okayama University uncover a groundbreaking inhibitor aimed at ...

Few effective treatments exist to treat neurodegenerative diseases such as Alzheimer's disease (AD), Parkinson's disease (PD), and amyotrophic lateral sclerosis (ALS). 1 Existing treatments focus on ...