The tissue adjacent to a tumor behaves differently than areas farther away: The tumor’s cancerous cells influence their surroundings, blocking the body’s immune defenses and creating a sort of haven ...
The cancer stem cell (CSC) paradigm is pivotal for understanding tumor progression, relapses, and therapeutic failure. Endowed with self-renewal, ...
When cancer cells die, macrophages consume them and produce inflammatory cytokines. This activates JAK and STAT proteins in living cancer cells, enabling them to produce their own Upd3 and creating a ...
Researchers at the University of California San Diego School of Medicine have identified a promising new therapy for triple-negative breast cancer (TNBC), which is among the most aggressive and ...
Throughout the past decade, Northwestern University scientists have uncovered a striking principle of vaccine design: Performance depends not only on vaccine components but also on vaccine structure.
Immune checkpoint inhibitors (ICIs), a powerful form of immunotherapy, have revolutionized cancer treatment by unleashing the body's own immune system to fight tumors. These compounds target the ...
In a city, coworking hubs bring people and ideas together. Inside cancer cells, similar hubs form—but instead of fueling progress, they supercharge disease. That's what researchers at the Texas A&M ...
TNBCs rely on fatty acid oxidization (FAO) to fuel tumor growth by breaking down surrounding adipose tissue through lipolysis. Gap junctions, particularly involving GJB3 and connexin 31 (Cx31), ...
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