DNA can be more than just a double helix. When four strands are folded into a compact bundle, they form a G-quadruplex (G4).

DNA replication in eukaryotic cells is a highly coordinated, multi-step process that ensures precise duplication of the genome prior to cell division. In late mitosis and early G1 phase, the Origin ...

The ATR–ATRIP kinase complex safeguards genome integrity by coordinating cellular responses to DNA damage and replication stress. Two recent cryo-EM studies resolve the structural basis of ATR–ATRIP ...

An international collaboration steered by David Cortez, Richard N. Armstrong, Ph.D. Chair for Innovation in Biochemistry, explored how cells tolerate DNA damage and genome instability—and they arrived ...

A new discovery by researchers at the RIKEN Center for Biosystems Dynamics (BDR) in Japan upends decades of assumptions regarding DNA replication. Led by Ichiro Hiratani and colleagues, the ...

At the scale of individual cells, the human body is constantly in motion. Every second, millions of cells divide, particularly in tissues such as the bone marrow, intestine and skin; neurons and heart ...

DNA replication is a tightly controlled process that copies the genetic code, allowing its instructions to be conveyed from one generation of cells to the next. In diseases like cancer, these ...

A protein that is involved in determining which enzymes cut or unwind DNA during the replication process has been identified. A protein that is involved in determining which enzymes cut or unwind DNA ...

Every embryo begins with a race against time. Primordial germ cells, the rapidly dividing precursors that ultimately give rise to eggs and sperm, must copy and safeguard their entire genome over and ...

For the first time, scientists have witnessed the very moment DNA begins to unravel, revealing a necessary molecular event for DNA to be the molecule that codes all life. A new study from King ...

King Abdullah University of Science & Technology (KAUST)Mar 19 2025 Reviewed For the first time, scientists have witnessed the very moment DNA begins to unravel, revealing a necessary molecular event ...