G protein-coupled receptor 84 (GPR84) is a member of the rhodopsin-like receptor family that has attracted considerable interest owing to its role in linking fatty acid metabolism with inflammatory ...

The interplay between G protein-coupled receptors (GPCRs) and fatty acid metabolism is emerging as a pivotal aspect in the pathogenesis and treatment of type 2 diabetes. Receptors such as free fatty ...

A GPS-like technique has been used to track G protein-coupled receptor movement, revealing how these essential receptors function. Although G protein-coupled receptors (GPCRs) are crucial to the ...

A recent study published in Engineering delves into the complex mechanisms of drug addiction, highlighting the crucial role of astrocytic G protein-coupled receptors (GPCRs). This research offers ...

A research team of the University Medical Center Mainz has succeeded in observing for the first time how G protein-coupled receptors in living cells actually respond to activating substances. The ...

Lefkowitz started to trace cell receptors in 1968. Using radioactivity, he managed to unveil several receptors, including one for adrenalin, the β-adrenergic receptor. His team then extracted the ...

G-protein-coupled receptors (GPCRs) are one of the largest families of cell surface proteins in the human body that recognize hormones, neurotransmitters, and drugs. These receptors regulate a wide ...

Structure and the tethered activation mechanism of aGPCRs. (A) The basic structure of aGPCRs. This article highlights the critical role of mechanosensitive aGPCRs in human health and disease, setting ...

Tectonic Therapeutic, Inc. (NASDAQ: TECX) (“Tectonic”), a clinical-stage biotechnology company focused on the discovery and development of therapeutic proteins and antibodies that modulate the ...

A preliminary study of people with diabetes suggests that use of glucose-lowering GLP-1 drugs may be linked to a lower risk of developing epilepsy. The study was published in Neurology. A systematic ...