Modern crop breeding is entering a new era of genome design, led by genome editing technologies as mainstream tools for targeted genome modification. In a review published in Nature Reviews Genetics, ...

The Human Genome Project changed everything. A map of the entire human sequence of DNA was the starting point for an enormous number of discoveries, from disease genes to how humans evolved. But DNA ...

Genome editing is a powerful biotechnology tool that allows scientists to make precise changes to an organism's DNA. It involves the use of specialized enzymes, known as engineered nucleases or ...

An important DNA modification is methylation, or the addition of a methyl group to the 5th carbon of cytosine. This forms 5-methylcytosine (5mC), typically associated with repression of gene ...

The prime editor is a fusion protein consisting of a catalytically impaired Cas9 nickase (Cas9n) and an engineered reverse transcriptase (RT). The Cas9n is guided by a prime editing guide RNA (pegRNA) ...

The discovery of CRISPR-Cas9’s gene-editing prowess revolutionized genetic engineering just over a decade ago. Now it appears that genetic engineering technology may be taking its next big leap.

A new liquid biopsy developed by researchers at the University of Chicago is offering a powerful new window into cancer’s earliest stages by flagging subtle shifts in the gut microbiome. Unlike ...