Immunoglobulin heavy chain variable ( IGHV) testing has become an important prognostic and therapeutic factor in chronic ...

In a recent study published in Immunity, researchers isolated SARS-CoV-2 spike (S) protein-targeted mAbs (monoclonal antibodies) from convalescent healthcare workers (HCWs), emphasizing the IGHV1-69 ...

Elevated immunoglobulin free light chain (FLC) level and abnormal FLC ratio are commonly seen in multiple myeloma (MM) and have prognostic implications. We hypothesized that presence of immunoglobin ...

Although the presence of an unmutated IgV H gene is strongly associated with the expression of ZAP-70, ZAP-70 is a stronger predictor of the need for treatment in B-cell CLL. Clinical and ...

Figure 1: STAT5 regulates rearrangement and germline transcription of distal V H J558 genes. Figure 2: STAT5 is required for distal V H J558 gene transcription but not for nuclear repositioning and ...

PNAS is the world's most-cited multidisciplinary scientific serial. It publishes high-impact research reports, commentaries, perspectives, reviews, colloquium papers, and actions of the Academy. In ...

Correlations Between O6-Methylguanine DNA Methyltransferase Promoter Methylation Status, 1p and 19q Deletions, and Response to Temozolomide in Anaplastic and Recurrent Oligodendroglioma: A Prospective ...

Researchers at the University of Eastern Finland and their international collaborators have identified key developmental and ...

This is a preview. Log in through your library . Abstract A rat monoclonal antibody specific for immunoglobulin (Ig) heavy chain binding protein (BiP) has allowed the examination of the association of ...

A new analysis shows the two major CLL subtypes likely arise from distinct points in B cell development. Mutated CLL resembles mature memory B cells, while unmutated CLL aligns with an earlier ...

Less than two percent of the human genome produces proteins, yet most of it is transcribed into RNA. Recent studies have been discovering a plethora of regulatory roles for noncoding RNA in diverse ...