The San Francisco 49ers and Arizona Cardinals will meet on Sunday afternoon at State Farm Stadium, with Kyle Shanahan's squad looking to sweep the season series against their division rival.

See who's in and who's out for the Week 11 matchup between the San Francisco 49ers and Arizona Cardinals on November 16, 2025.

Both the 49ers and Cardinals are dealing with major injuries heading into Week 11, with several star players appearing on the first injury report.

Cornerback Deommodore Lenoir (calf) is the only 49ers player with an injury designation. He is questionable after being downgraded to out of practice on Friday. The team added him to the report on Thursday. Defensive tackle Alfred Collins (hip) and linebacker Dee Winters (knee/knee) returned to full participation in Friday’s practice.

The Arizona Cardinals have a lengthy injury report ahead of Week 11, with seven players officially ruled out against the San Francisco 49ers.

For the Cardinals, all of Marvin Harrison Jr. (illness), Will Johnson (back/hip), Dadrion Taylor-Demerson (ankle), Jonah Williams (shoulder), Mack Wilson (ribs), Baron Browning (concussion) and Hayden Conner (knee) are out.

San Francisco (6-4) is looking to get back on track after dropping a 42-26 decision to the Los Angeles Rams, who are currently 1.5 games ahead of the 49ers in the NFC West standings. Speaking of the NFC West,