Nearly 100 years ago, a seemingly simple discovery revolutionized the microscope. The introduction of phase contrast, which garnered a Nobel Prize in 1953, brought into clear view structures inside ...

Physicists have demonstrated a laser-based method that enables a cryogenic electron microscope to image small protein structures with greater detail than previously possible. The laser phase plate ...

Key points of this articleIn 1958, Nippon Kogaku packed a full-scale microscope capable of 100x oil immersion, phase contrast ...

The invention that first enabled researchers to see clear images of living cells was the phase-contrast microscope, which won its inventor, Frits Zernike, a Nobel Prize in 1932. Prior to Zernike's ...

Quantitative phase imaging is a powerful, non-invasive and quantitative microscopy technique that allows multi-scale imaging of cellular systems, explain Mustafa Mir and Gabriel Popescu Imaging by ...

Scientists categorize most imaging methods into two major types: label-free and fluorescence microscopy. However, these techniques do not exist in isolation, as the majority of fluorescence ...

a, An axi-symmetric binary phase filter (BPF) and image reconstruction network are jointly learned through the physics-informed neural network. The learned BPF is fabricated and inserted in a pupil ...