Biologists are very interested in how proteins, lipids and other compounds are organized and interact in systems. Very few organizational details can be gained by using standard transmission-based ...

Understanding how living cells grow, respond to stimuli, and change over time is central to modern cell biology and drug discovery. Many traditional imaging approaches rely on fluorescent labels, ...

In this interview, Claudia Florindo talks about what matters when comparing benchtop fluorescence microscopes. What prompted Oxford Instruments to produce this buyer's guide, and what gaps or ...

Selective plane illumination microscopy (SPIM) is a type of light sheet fluorescence microscopy (LSFM), which is one such 3D imaging technique employing a thin sheet of light to illuminate cleared ...

Multiphoton microscopy is used in biomedical research to study cells and tissues. Today, so-called two-photon microscopy is used to study processes within cells, but the technique has limitations in ...

An international collaboration led by the University Medical Center Göttingen (UMG), Germany, has developed a labeling method that distinguishes fluorescent labels not by color but by how long it ...

descSPIM enables three-dimensional imaging of diverse tissues like neural cells and cancerous tumors. The widespread dissemination and adoption of descSPIM can accelerate biomedical discoveries. Three ...

(A–C) Representative images reconstructed by conventional method (left) and new method (right) of microtubules, nuclear pore complexes and F-actin samples. The regions enclosed by the white boxes are ...

Using a tiny, spherical glass lens sandwiched between two brass plates, the seventeenth century Dutch microscopist Antonie van Leeuwenhoek was the first to officially describe red blood cells and ...

For centuries, scientists have used microscopes to magnify and peer into a world invisible to the naked eye. The earliest instruments were simple lens-filled tubes, the best of which revealed the ...