An interview with David M. Sabatini, M.D., Ph.D., conducted by April Cashin-Garbutt, MA (Cantab). Can you please give a brief introduction to the mechanistic target of rapamycin (mTOR) cellular ...

mTOR signaling has emerged as a critical integrator of neuronal activity and synaptic inputs that in turn affect many cell biological processes, including autophagy, protein synthesis, lipid synthesis ...

The protein mTOR is a central controller of growth and metabolism. Deregulation of mTOR signaling increases the risk of developing metabolic diseases such as diabetes, obesity and cancer. Researchers ...

Sepsis, one of the most acute and serious disease complications in the intensive care unit, is caused by various infections and results in life-threatening organ dysfunction. The intestinal barrier ...

As the cell's molecular control center, the mTor kinase regulates cellular metabolism, growth and division. However, in cells affected by pathological change, the regulation goes awry. Scientists have ...

CINCINNATI--Soon after rapamycin, the first mTOR inhibitor, emerged in 1990s as a potential treatment against unwanted cell proliferation, many cancer experts had hoped emerging drugs targeting mTOR ...

Renal cell carcinoma (RCC) develops resistance to most of the conventional therapies. In recent years inhibitors are being used to interfere with growth of cancer cells at molecular level and are ...

Potential Pitfalls of the Rapid Uptake of New Technology in Surgery: Can Comparative Effectiveness Research Help? Mutations of the PIK3CA gene may predict response to phosphatidylinositol 3-kinase ...

Prognostic value of hedgehog signaling in cervical carcinoma. Background: Although improvements in the treatment of ovarian cancer have increased the global prognosis, the metastatic disease is still ...

A detailed study of these mice revealed that gene-influenced lifespan extension did not affect every tissue and organ the same way. For example, the mice retained better memory and balance as they ...