Presbyopia-correcting eye drops enhance depth of focus by constricting the pupil, using cholinergic agonists to activate the iris sphincter muscle. FDA-approved options include pilocarpine, aceclidine ...
Credit: Lenz Therapeutics. Vizz eye drops contain a cholinergic muscarinic agonist that causes contraction of the iris sphincter muscle, resulting in a pinhole effect that extends focus depth to ...
Version of Record: This is the final version of the article. Tubert C. et al. investigated the role of dopamine D5 receptors (D5R) and their downstream potassium channel, Kv1, in the striatal ...
The authors investigated the mechanisms underlying the pause in striatal cholinergic interneurons (SCINs) induced by thalamic input, identifying that Kv1 channels play a key role in this ...
Nicotinic acetylcholine receptors, especially α7 (nAChRα7), form Ca 2+ channels and are expressed on a variety of neuronal and nonneuronal cells. Also, megakaryocytic cells have been shown to contain ...
New M1 orthosteric agonist protects against scopolamine-induced damage in in vitro Alzheimer’s disease model Dec. 27, 2024 ...
CSF-1 consistently reduces pupil size with an overall gain in near and distance vision when administered to patients with presbyopia. Pilocarpine is a cholinergic muscarinic receptor agonist that ...
In addition to Cobenfy being approved for schizophrenia, there are other drugs with novel mechanisms being studied that may mean combination therapies or, at least, more options for patients in the ...
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