DNA can be more than just a double helix. When four strands are folded into a compact bundle, they form a G-quadruplex (G4).

The ATR–ATRIP kinase complex safeguards genome integrity by coordinating cellular responses to DNA damage and replication stress. Two recent cryo-EM studies resolve the structural basis of ATR–ATRIP ...

Repetitive sequences make extrachromosomal DNA vulnerable to breaks, which could be exploited for therapy — but might also promote tumour evolution.

At the scale of individual cells, the human body is constantly in motion. Every second, millions of cells divide, particularly in tissues such as the bone marrow, intestine and skin; neurons and heart ...

A new critical review in Molecular Biology Reports systematically compares the biochemical, cellular, and genome-wide assays ...

A barcoded shuttle-vector sequencing assay shows that chronic low-dose gamma irradiation amplifies pre-existing mutation ...

The Okazaki Fragments That Solved the Mystery of DNA Replication1. The Mystery That Could Not Be Solved by the Discovery of ...

Life on Earth writes its blueprints using only four types of letters.A, T, G, and C. If the sequence changes, the organism ...

Anthropic's Claude AI discovers a novel enzyme system in bacterial DNA, marking a breakthrough in AI-assisted genomic ...

UC San Diego structures show E. coli RNA polymerase reads four synthetic DNA letters the same way it reads the natural four.

Harvard researchers discovered how human cells identify invading viruses and initiate an immune defense within one hour of ...