Immunohistochemistry for caveolin-1 and activated components of the AKT/mTOR pathway in clinically confined RCC. Caveolin-1 staining was comparable to that previously described (Campbell et al ...

By measuring the number and variety of phosphate tags on proteins controlled by Akt in the tissue samples, the researchers could get a sense of the overall activity of the Akt-mTOR pathway.

KEY POINTSThe PI3K/AKT/mTOR pathway is an established oncogenic driver in a variety of tumor types.Inhibitors of this pathway are already in clinical testing, ... Tuberous sclerosis complex (TSC) is a ...

Background: Although improvements in the treatment of ovarian cancer have increased the global prognosis, the metastatic disease is still an incurable situation. Therefore, it is necessary to identify ...

Treating the genetically engineered mice with rapamycin, a drug that targets mTOR, not only prevented excessive protein production in mice with a condition like Parkinson's disease, but also eased ...

Treating the genetically engineered mice with rapamycin, a drug that targets mTOR, not only prevented excessive protein production in mice with a condition like Parkinson's disease, but also eased ...