DNA can be more than just a double helix. When four strands are folded into a compact bundle, they form a G-quadruplex (G4).

The ATR–ATRIP kinase complex safeguards genome integrity by coordinating cellular responses to DNA damage and replication stress. Two recent cryo-EM studies resolve the structural basis of ATR–ATRIP ...

Repetitive sequences make extrachromosomal DNA vulnerable to breaks, which could be exploited for therapy — but might also promote tumour evolution.

I have completed a master's degree in a science-related graduate school and work as a researcher at a manufacturing company.

At the scale of individual cells, the human body is constantly in motion. Every second, millions of cells divide, particularly in tissues such as the bone marrow, intestine and skin; neurons and heart ...

The Okazaki Fragments That Solved the Mystery of DNA Replication1. The Mystery That Could Not Be Solved by the Discovery of ...

Every embryo begins with a race against time. Primordial germ cells, the rapidly dividing precursors that ultimately give rise to eggs and sperm, must copy and safeguard their entire genome over and ...

A new study reports that the circadian clock gene BMAL1 and the cell cycle checkpoint regulator WEE1 are significantly ...

Ten established diet-quality scores, among them the Mediterranean, DASH, MIND and Nordic patterns, were each associated with slower biological aging in about 7,500 German adults. The German Center for ...

Anthropic's Claude AI discovers a novel enzyme system in bacterial DNA, marking a breakthrough in AI-assisted genomic ...

UC San Diego structures show E. coli RNA polymerase reads four synthetic DNA letters the same way it reads the natural four.