Chronic osteoarthritis (OA) pain is a complex nociplastic condition that affects humans, as well as cats and dogs. This review summarizes the physiology of pain in healthy individuals, the ...

Researchers have developed and validated predictive models to estimate the core pain-processing mechanisms using a limited set of easily accessible, routinely obtainable clinical measures. Researchers ...

Researchers at Tulane University, with a team of colleagues from eight other universities, have discovered a new nerve cell signaling mechanism that could transform our understanding of pain and lead ...

A breakthrough discovery reveals how the SLC45A4 gene fine-tunes polyamine transport in sensory neurons, reshaping our understanding of pain and opening new paths for targeted therapies. Study: ...

Summary: Pain isn’t just physical—it can be socially and emotionally transmitted. New research shows that ultrasonic vocalizations emitted by mice in pain trigger hyperalgesia in nearby mice, even ...

Scientists have discovered a brain circuit that gives pain its emotional sting, explaining why some hurts linger as suffering. The breakthrough challenges our beliefs about how we process pain and may ...

Pain isn't just a physical sensation-it also carries emotional weight. That distress, anguish, and anxiety can turn a fleeting injury into long-term suffering. Researchers at the Salk Institute have ...

What if your brain is the reason some pain feels unbearable? Scientists at the Salk Institute have discovered a hidden brain circuit that gives pain its emotional punch—essentially transforming ...

But Bongiorno wasn’t asking for drugs — she simply wanted help. For two years, Bongiorno, 54, had been living with pain that she describes as a deep burning sensation far worse than kidney stones or ...

Salk scientists uncover a key neural circuit in mice that gives pain its emotional punch, opening new doors for treating fibromyalgia, migraine, and PTSD LA JOLLA (July 9, 2025)—Pain isn’t just a ...

When pain strikes from multiple sources—such as a paper cut followed by contact with hot water—the experience can feel disproportionately intense. But is this agony merely additive, or does the brain ...