Before their Week 11 matchup against the Seattle Seahawks, we'll be making our San Francisco 49ers bold predictions ...

Don’t expect the San Francisco 49ers to take their foot off the gas in their usage of running back Christian McCaffrey.

When WR Deebo Samuel and the San Francisco 49ers square off with the Seattle Seahawks in Week 11 on Sunday at 4:05 PM ET, ...

The San Francisco 49ers are teetering on the brink of potential disaster on the injury front as they prepare for their Week ...

Watch "49ers Now" with Matt Maiocco and Jennifer Lee Chan at 4 p.m. PT today from Santa Clara, streaming live on the NBC ...

Tampa Bay Buccaneers Tackle Luke Goedeke was mic'd up for Week 10's Salute to Service game against the San Francisco 49ers. Hear from Luke in this week's edition of Mic'd Up.

Christian McCaffrey had 107 yards from scrimmage in his season debut. The 49ers are a different team when McCaffrey is on the ...

SANTA CLARA – Deebo Samuel marveled at Steph Curry and the Warriors as he sat courtside Tuesday night with fellow 49ers wide ...

Listen in as players from the 49ers locker room shared their excitement for DB Deommodore Lenoir's five-year contract ...

San Francisco 49ers QB Brock Purdy spoke about the team's mindset heading into #SEAvsSF and emphasized his on-field ...

Cornerback Deommodore Lenoir, who has emerged as a cornerstone of the defense, agreed to a five-year extension.

Knox argues San Francisco 49ers safety Talanoa Hufanga could be just what the Saints defense has been missing: Injuries have ...