Discover how subtle chemical changes to DNA, beyond the genetic code, dynamically shape gene activity, cellular identity, and overall biological function.

Key players in epigenetic control are chemical modifications to DNA, histone, and non-histone chromosomal proteins, which establish a complex regulatory network that controls genome function.

DNA modifications refer to a variety of chemical alterations to the nucleotides in DNA, which mediate important biological functions and are increasingly recognized for their significance.

Aug 3, 2017 · How Does Genome Editing Work? Techniques to modify DNA in the genome have existed for several decades, but the conversation about the science and ethics of genome editing has grown …

Dec 5, 2025 · Gene editing is performed using enzymes, particularly nucleases that have been engineered to target a specific DNA sequence, where they introduce cuts into the DNA strands, …

Jun 11, 2025 · DNA modification, also known as genetic editing, is the process of making targeted changes to the DNA sequence of an organism. This technology has revolutionized the field of …

This book provides an overview of methods and experimental protocols that are currently used to analyze the presence and abundance of non-canonical DNA nucleotides in different biological systems.

Aug 19, 2025 · To understand the functional genomic roles of DNA modifications, it is critical to accurately map their diverse chemical forms with single-nucleotide precision in complex genomes, …

DNA modifications are widespread in different species and are indispensable in multiple biological processes, such as gene regulation and tumorigenesis, genomic imprinting, X-chromosome …

What Does Alteration Mean? At its core, alteration involves modifying the structure or sequence of DNA. This can involve simple tweaks or complex modifications that essentially reshape the genetic blueprint.