In biology, reprogramming refers to erasure and remodeling of epigenetic marks, such as DNA methylation, during mammalian development or in cell culture. [1] Such control is also often …

Apr 9, 2025 · This review summarizes the recent advances in cell reprogramming mediated by transcription factors or chemical molecules, followed by elaborating on the important roles of …

Dec 9, 2025 · Cell reprogramming is the process of reverting mature, specialised cells into induced pluripotent stem cells. Reprogramming also refers to the erasure and re-establishment of epigenetic …

“By attempting to reprogram a population of progenitor cells, you have a way to increase efficiency,” Hochedlinger said. Approximately 300 cells out of 1,000 successfully transform into an iPS cell by …

To return an adult cell to a stem cell state, scientists package a stretch of DNA (called a plasmid) that carries the reprogramming instructions with a solution of lipids that help it melt through the cell …

Dec 2, 2025 · While the terms sound and look very similar, there is an important distinction. Cell reprogramming is the act of reverting mature, specialised cells into induced pluripotent stem cells, …

Reprogramming is the result of large-scale changes in the epigenetic profile and gene-expression pattern of a cell, induced by the over-expression of key transcription factors, which regulate and …

Aug 24, 2023 · Chemical reprogramming offers an unprecedented opportunity to control somatic cell fate and generate desired cell types including pluripotent stem cells for applications in biomedicine in a …

Mar 27, 2025 · This review summarizes the recent advances in cell reprogramming mediated by transcription factors or chemical molecules, followed by elaborating on the important roles of …

This Review discusses the evolution of direct reprogramming from a transcription factor-based method to a small-molecule-driven approach, the recent progress in enhancing reprogrammed cell …